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M9650020.TXT
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1996-03-09
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Document 0020
DOCN M9650020
TI Host dependent variation of hepatitis C virus: phylogenetic analyses.
DT 9605
AU Maekawa S; Enomoto N; Kurosaki M; Marumo F; Sato C; Second Department of
Internal Medicine, Tokyo Medical and Dental; University, Japan.
SO Arch Virol. 1995;140(12):2123-33. Unique Identifier : AIDSLINE
MED/96140609
AB Hepatitis C virus quasispecies in six patients from three families were
separated by single strand conformation polymorphism analysis and by
determination of nucleotide sequences of envelope regions containing the
E1 gene segment and hypervariable region-1 of each quasispecies. Four of
the six patients had multiple quasispecies. Phylogenetic analyses
indicated that all quasispecies from one individual were highly
homologous to each other. The homology was higher in the E1 gene segment
than in hypervariable region-1. Furthermore, all quasispecies found in
members of one family (husband and wife) were also highly homologous,
suggesting direct intrafamilial transmission. The direction of hepatitis
C virus variation in hypervariable region-1, however, seems to differ
depending on the host in intrafamilial transmission.
DE Adolescence Aged Base Sequence Case Report Comparative Study DNA
Primers Female Genes, env Hepatitis C/BLOOD Hepatitis C
Viruses/*CLASSIFICATION/*GENETICS/ISOLATION & PURIF Human Male Middle
Age Molecular Sequence Data *Phylogeny Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational RNA,
Viral/ANALYSIS/GENETICS Support, Non-U.S. Gov't *Variation (Genetics)
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).